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Since the introduction of surface-enhanced Raman spectroscopy (SERS) in the 1970s, the introduction of precious metal substrates has increased Raman detection sensitivity by millions of times, overcoming the shortcomings of traditional Raman spectroscopy and the inherent weakness of the signal, making Raman Detection has been widely used in food safety, environmental monitoring, life sciences and other fields, and has quickly grown into one of the most sensitive surface species spectroscopy detection technology. However, people are delighted and regretfully discovered that SERS is only highly active on the rough surfaces of precious metals such as gold, silver, and copper, and the choice of substrates is very limited; and in practical applications, gold, silver, and copper-enhanced materials are also susceptible. Other materials interfere with poor stability. Exploring new, high-performance non-metallic substrates has always been one of the most important research directions in SERS technology.
Recently, Zhao Zhigang, a researcher at the Suzhou Institute of Nanotechnology and Nanobionics of the Chinese Academy of Sciences, collaborated with researchers from the research group of the Faculty of Wood Chemistry of Suzhou University to discuss changes in stoichiometry or surface oxygen defect concentration of semiconductive transition metal oxide nanoparticles. , to enhance the signal of non-(weak) SERS active material surface species. Under the guidance of this academic thought, the oxygen-deficient W18O49 sea urchin-like nanoparticle was used as the SERS substrate to obtain excellent SERS performance with high sensitivity and high detection limit. The detection limit can be as low as 10-7 M, and the enhancement factor can reach 3.4×105. It is one of the most outstanding semiconductor SERS substrate materials that have been reported so far, and is close to precious metal materials that have no "hot spot" effect.
This work confirms that proper modulation of oxygen deficiencies in semiconductor oxides can be used as an effective means of significantly increasing its SERS performance, breaking through the limitations of conventional SERS technology in precious metal substrates, and further broadening the use of semiconductor oxides as a substrate material in SERS detection. The scope of application. The relevant results were published in academic journal Nature Communication (Volume 6, Article number: 7800, July 17, 2015).
This work was strongly supported by the National Natural Science Foundation of China (51372266 and 51402204).
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