Dasatinib monohydrate Powder CAS 863127-77-9 inhibitor Pharmaceutical
Product name:Dasatinib monohydrate
Other name:Dasatinib hydrate;BMS-354825
CAS No:863127-77-9
Molecular formula:C22H28ClN7O3S
Molecular weight:506.02082
EINECS:N/A
Appearance:Off-white powder
Catalogue:Pharmaceutical materials.
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| Items of analysis | Specification | Results |
| Appearance | White to off white powder | Off-white powder |
| Identification | A: IR absorption B: Thin-layer chromatographic identification test | Conforms |
| Identification | IR, HPLC | Complies |
| crystalline form | H1-7 | Complies |
| Water(KF) | 3.6-4.5% | 3.59% |
| Residue on ignition | ≤ 0.5% | 0.22% |
| Related Impurity by HPLC | Max Single impurity ≤0.1%;Total impurity ≤1.0% | 0.08%;0.15% |
| Purity (HPLC) | 99.0% | 99.85 % |
What is Dasatinib monohydrate
Dasatinib monohydrate is a pyrimidine and thiazole derived ANTINEOPLASTIC AGENT and PROTEIN KINASE INHIBITOR of BCR-ABL KINASE. It is used in the treatment of patients with CHRONIC MYELOID LEUKEMIA who are resistant or intolerant to IMATINIB.
BMS-354825 is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes.
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2,Our prices are the best because of the discounts that we give to all our buyers. We give very good discounts which makes our prices outstanding in the market.
3,Genuine and 100% Guarantee on all orders you place. We Have the Best you will come across Online. We have adequate stock, and can arrange the delivery within 24hours when receiving the payment. Tracking number would be informed quickly after shipment.
4,We have the best customer service and excellent shipment ability. Contact us to have a full list of our products and price list.
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Dasatinib monohydrate Powder CAS 863127-77-9 inhibitor Pharmaceutical
Product name:Dasatinib monohydrate
Other name:Dasatinib hydrate;BMS-354825
CAS No:863127-77-9
Molecular formula:C22H28ClN7O3S
Molecular weight:506.02082
EINECS:N/A
Appearance:Off-white powder
Catalogue:Pharmaceutical materials.
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| Items of analysis | Specification | Results |
| Appearance | White to off white powder | Off-white powder |
| Identification | A: IR absorption B: Thin-layer chromatographic identification test | Conforms |
| Identification | IR, HPLC | Complies |
| crystalline form | H1-7 | Complies |
| Water(KF) | 3.6-4.5% | 3.59% |
| Residue on ignition | ≤ 0.5% | 0.22% |
| Related Impurity by HPLC | Max Single impurity ≤0.1%;Total impurity ≤1.0% | 0.08%;0.15% |
| Purity (HPLC) | 99.0% | 99.85 % |
What is Dasatinib monohydrate
Dasatinib monohydrate is a pyrimidine and thiazole derived ANTINEOPLASTIC AGENT and PROTEIN KINASE INHIBITOR of BCR-ABL KINASE. It is used in the treatment of patients with CHRONIC MYELOID LEUKEMIA who are resistant or intolerant to IMATINIB.
BMS-354825 is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes.
Our advantage:
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2,Our prices are the best because of the discounts that we give to all our buyers. We give very good discounts which makes our prices outstanding in the market.
3,Genuine and 100% Guarantee on all orders you place. We Have the Best you will come across Online. We have adequate stock, and can arrange the delivery within 24hours when receiving the payment. Tracking number would be informed quickly after shipment.
4,We have the best customer service and excellent shipment ability. Contact us to have a full list of our products and price list.
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